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. 2021 Jan 20;22(3):987. doi: 10.3390/ijms22030987

Figure 2.

Figure 2

Schematic representation of the expression and localization of Cx43 in pulmonary hypertension (PH). In the vasculature, the amount of Cx43 depends on the exact form of PH. In the right ventricle (RV), PH is associated with a downregulation of Cx43 as well as with enhanced lateralization of the protein. Therapeutic approaches to treat PH can maintain Cx43 expression and localization. Schematic representation of the heart: copyright © 2005, Les Laboratoires Servier. PAH: pulmonary arterial hypertension.