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. 2021 Jan 20;22(3):999. doi: 10.3390/ijms22030999

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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WNK4 and WNK4-regulated channels in mice fed 2% KCl diets. Western blot analysis of (A) WNK4, (B) BK, and ROMK, (C) γ-ENaC, (E) NKCC2, and p-NKCC2, and (H) NCC and p-NCC in the kidney of MST^+/+ and MST3^−/− mice 8 weeks after the treatment with the control and 2% KCl diets for 16 days (n = 3 animals/group). The bar graph shows quantification of Western blot relative to the levels in the control group of WT mice. * p < 0.05 vs. the control group. Serial sections of the kidney of WT and MST3^−/− mice fed the control and 2% KCl diets were stained for γ-ENaC (D), NKCC2 (F,G, outlined images of F were enlarged using a 100× objective.), NCC (I), and MST3. G, glomerular; D1, early distal convoluted tubule; D2, late distal convoluted tubule; CN, connecting tubule.

WNK4 and WNK4-regulated channels in mice fed 2% KCl diets. Western blot analysis of (A) WNK4, (B) BK, and ROMK, (C) γ-ENaC, (E) NKCC2, and p-NKCC2, and (H) NCC and p-NCC in the kidney of MST^+/+ and MST3^−/− mice 8 weeks after the treatment with the control and 2% KCl diets for 16 days (n = 3 animals/group). The bar graph shows quantification of Western blot relative to the levels in the control group of WT mice. * p < 0.05 vs. the control group. Serial sections of the kidney of WT and MST3^−/− mice fed the control and 2% KCl diets were stained for γ-ENaC (D), NKCC2 (F,G, outlined images of F were enlarged using a 100× objective.), NCC (I), and MST3. G, glomerular; D1, early distal convoluted tubule; D2, late distal convoluted tubule; CN, connecting tubule.