Table 5.
List of the available structures of the complexes between protein inhibitors and cysteine proteases: calpastatins, securing, and designed ankyrin repeat proteins (DARPins).
| Protein Inhibitor | Cysteine Protease | ||||||
|---|---|---|---|---|---|---|---|
| MEROPS ID | Name | Organism | MEROPS ID | Name | Organism | PDB ID | Reference |
| I27 | Calpastatin family | ||||||
| I27.001 | calpastatin | Rattus norvegicus | C02.002 | calpain-2 | Rattus norvegicus | 3DF0 | [99] |
| I27.001 | calpastatin | Rattus norvegicus | C02.002 | calpain-2 | Rattus norvegicus | 3BOW | [148] |
| securin | Saccharomyces cerevisiae S288C | C50.001 | separin | Saccharomyces cerevisiae S288C | 5U1S/5U1T | [100] | |
| Interactor of FizzY protein | Caenorhabditis elegans | C50.004 | separase | Caenorhabditis elegans | 5MZ6 | [149] | |
| DARPin | synthetic construct | C14.006 | Caspase-2 | Homo sapiens | 2P2C | [150] | |
| DARPin-3.4 | synthetic construct | C14.003 | Caspase-3 | Homo sapiens | 2XZD | [151] | |
| DARPin C7_16 | synthetic construct | C14.004 | Caspase-7 | Homo sapiens | 4JB8 | [152] | |
| DARPin D7.18 | synthetic construct | C14.004 | Caspase-7 | Homo sapiens | 4LSZ | [153] | |
| DARPin 8h6 | synthetic construct | C01.060 | Cathepsin B | Homo sapiens | 5MBM | [154] | |
| DARPin 81 | synthetic construct | C01.060 | Cathepsin B | Homo sapiens | 5MBL | [154] | |