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Beta cells display a heterogenous response to glucose including differences in excitability levels. A subpopulation of “hub” cells has been described that account for up to 10% of total beta cells. These “hub” cells, as opposed to “follower” beta cells, exert an acute control over islet response to high glucose and may therefore determine a key component of beta cell connectivity by coordinating the calcium response across the islet, acting as “pacemakers”.
