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. 2021 Jan 20;22(3):991. doi: 10.3390/ijms22030991

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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PAR2 activation increased the frequency of the spontaneous excitatory postsynaptic currents (sEPSCs) under the inflammatory conditions. (A) Application of PAR2 AP (4 min) on an acute spinal cord slice prepared 24 h after the carrageenan injection increased the sEPSC frequency as documented in the recording from one superficial dorsal horn neuron. (B) Application of PAR2 AP increased the average sEPSC frequency (n = 13; Kruskal-Wallis one-way ANOVA, * p < 0.05). (C) Pretreatment and co-application of the TRPV1 antagonist SB 366791 (SB, n = 8) attenuated the PAR2 AP-induced effect on the sEPSC frequency. Pretreatment and co-application of staurosporine (STP, n = 12) prevented the excitatory effect of PAR2 AP. Application of the PAR2 antagonist (n = 8) decreased the frequency of the sEPSC. Statistical analysis: one-way ANOVA followed by SNK test. Statistical symbols: ** p < 0.01 and *** p < 0.001 versus PAR2 AP and + p < 0.05 versus the PAR2 antagonist.