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. 2021 Jan 20;11:599588. doi: 10.3389/fpsyt.2020.599588

Figure 3.

Figure 3

Single administration of ketamine produced a rapid (30 min) and sustained (24 h) reduction in immobility in the FST and transiently reduced LMA (30 min) in WKY rats. (A) Dose-response efficacy of acute ketamine (1, 3, and 5 mg/kg, s.c.) 30 min post-administration in the FST. (B) FST 30 min and 24 h post-administration of ketamine (5 mg/kg, s.c.). (C) LMA 30 min and 24 h post-administration of ketamine (5 mg/kg, s.c.). Data are expressed as mean ± SEM, n = 8-10 per group. *p < 0.05, **p < 0.01, ***p < 0.001. WKY, Wistar Kyoto; FST, forced swim test; LMA, locomotor activity.