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. 2021 Jan 4;4:19. Originally published 2019 Jan 31. [Version 3] doi: 10.12688/wellcomeopenres.15056.3

Table 2. Individual patient data that will be requested from authors.

LAM= lipoarabinomannan NAAT= nucleic acid amplification test.

Clinical data at presentation Laboratory results
(blood)		 Laboratory results (CSF)
•   Age *
•   Sex *
•   Presence of extrapyramidal movements *
•   Presence of neck stiffness *
•   Duration of symptoms *
•   Focal neurological deficit (including cranial nerve palsy) *
•   Temperature *
•   Glasgow Coma Scale *
•   AVPU score * 		•   HIV sero-status *
•   Total leukocytes *
•   CD4 count *
•   Glucose * 		•   Appearance *
•   Total leukocytes *
•   Total neutrophils *
•   Total lymphocytes *
•   Protein *
•   Glucose *
•   Gram stain *
•   Adenosine deaminase activity *
•   Bacterial culture
•   India ink stain *
•   Cryptococcal antigen * and culture
•   Microscopy for acid-fast bacilli
•   Mycobacterial culture
•   NAAT for Mycobacterium tuberculosis
•   NAAT for any virus
•   Syphilis serology *
•   Any other test informing an alternative
diagnosis
Laboratory results (urine, sputum and serous
effusions)		 Radiological
investigations		 Autopsy
•   Urine LAM *
•   Microscopy for acid-fast bacilli *
•   Mycobacterial culture
•   NAAT for Mycobacterium tuberculosis * 		•   Chest X-ray *
•   Abdominal ultrasound
scan
•   CT brain
•   MRI brain		 •   Histological results from autopsy

*Factors chosen a priori to be used to develop the initial model.