Figure 5.

let-7d inhibits HMGA2 expression and prevents epithelial–mesenchymal transition (EMT) in intrauterine adhesions (IUA)-like mouse. (A) let-7d mRNA level, (B) HMGA2 mRNA level and (C) Representative images of HE, Mason staining, HMGA2, E-cad, N-cad and α-SMA in mice endometrial biopsies of the sham (n = 5), the curettage treatment (n = 5), the curettage with agomir negative control (C + agomir-NC, n = 5) treatment and the curettage with let-7d agomir (C + agomir-let-7d, n = 5) treatment group. Scale bars, 50 μm. The data are shown as the mean ± SD. *P < 0.05; **P < 0.01. Student’s t-tests were performed for panel A and B. The number above the asterisk in each panel is the fold difference.