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Brown adipose tissue (BAT) function is modulated by numerous rhythmic signals originating from other peripheral or central tissues as well as circulating metabolites such as glucose and fatty acids (FAs). The circadian clock in brown adipocytes is essential for proper BAT function. BAT produces heat via nonshivering thermogenesis, affecting body temperature. ANS indicates autonomic nervous system; CCK, cholecystokinin; SNS, sympathetic nervous system.
