Figure 8.

Aspirin inhibits the growth of HuCCT-1 cell xenografts in nude mice. (A) The tumors were significantly smaller in aspirin-treated mice than in vehicle-treated mice. Each point represents the mean ± standard deviation of 10 animals. ^**P<0.01 by mixed analysis of variance. (B) Relative quantification of miR-340-5p in tumor tissue of the three groups of xenografted mice. (C) Left image: H&E-stained images of the xenografted tumor tissues between the aspirin-treated and control mice (scale bar, 100 µm). Immunohistochemical staining of cyclin D1 between the aspirin-treated and control mice (scale bar, 20 µm). Right image: Cyclin D1-positive cells in the aspirin-treated groups were reduced in number compared with the control group as determined by one-way analysis of variance. ^*P<0.05 and ^**P<0.01. H&E, hematoxylin and eosin.