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. 2020 Dec 11;58(2):158–170. doi: 10.3892/ijo.2020.5158

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Copyright: © Pan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The Serine-glycine biosynthesis pathway. The glycolysis pathway and glutamine catabolism provide an intermediate metabolite, 3-PG, which is gradually catalyzed into serine by PHGDH, PSAT1 and PSPH. Finally, serine is converted into glycine by SHMT1/2. Yellow ovals represent metabolic enzymes. 3-PG, 3-phosphoglycerate; 3-PHP, 3-phosphate hydroxypyruvate; 3-Pser, 3-phosphoserine; α-KG, α-ketoglutarate; OAA, oxaloacetate; PHGDH, phosphoglycerate dehydrogenase; PSAT, phosphoserine aminotransferase; PSPH, phosphoserine phosphatase; SHMT, serine hydroxymethyltransferase; TCA, tricarboxylic acid.