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. 2021 Jan 5;58(2):211–225. doi: 10.3892/ijo.2021.5167

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Copyright: © Holzhauser et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Combinational effects of PI3K inhibitors, BYL719 and BEZ235, and FGFR inhibitors, JNJ-42756493 and AZD4547, on SK-N-AS, SK-N-BE(2)-C, SK-N-DZ, SK-N-FI and SK-N-SH cell lines. CIs were obtained by (A-E) the highest single agent approach, where CI >1 shows a negative combination effect, and (F-J) the median effect method, where CI >1.45 indicates antagonism, 0.7< CI >1.45 additive, and CI <0.7 synergistic combinational effects. CIs were calculated from the mean of 3 experiments analyzed by WST 1, at 24 h following treatment. x denotes r<0.85 in the median method; thus, the analysis could not proceed; o denotes CI >2, which indicates a negative combination effect. CI, combination index; NB, neuroblastoma; BYL, BYL719; BEZ, BEZ235; AZD, AZD4547; JNJ, JNJ-42756493.