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. 2020 Dec 14;58(2):145–157. doi: 10.3892/ijo.2020.5159

Figure 2.

Figure 2

SARS-CoV-2 alveolar infection in severe cases may promote acute respiratory distress syndrome (ARDS; box on upper right, red color). Therapeutic intervention with anti-PD-1 antibody may restore T-cell cytotoxicity towards alveolar infected cells and help optimal viral clearance (box on lower right, green color). SARS-CoV-2, severe acute respiratory syndrome associated coronavirus-2; ARDS, acute respiratory distress syndrome; IFN, interferon; TNF, tumor necrosis factor; PD-1, programmed death-1; PD-L1, PD ligand-1.