Figure 5.

The S. aureus Genetic Adhesion Network and anti-adhesive target space. The larger central nodes identify the host ligand in each screen (fibrinogen, fibronectin, and keratin). The smaller nodes radiating from these points indicate transposons inserted into genes that caused a significant reduction (Student's t test, p value ≤ 0.05; see Table 1 and Fig. S1) in adhesion to the host ligand they are linked. The node size for each gene reflects the percent adhesion compared with the parental strain (i.e. the larger the node the more pronounced the attenuated adhesion). The figure was generated using Cytoscape. Genes mazE (SAUSA300_2026), recD2 (SAUSA300_1576), rpiR (SAUSA300_2264), and ydiL (SAUSA300_1984) are names provided on the basis of their predicted structure and function. One gene, labeled hypo (hypothetical protein), is unannotated (SAUSA300_0602).