Figure 1.

ECM signaling in autophagy and angiogenesis.A, an overview of cell-surface proteoglycan signaling of endorepellin, decorin, endostatin, biglycan, and lumican resulting in modulations on autophagy and/or angiogenesis. Cell types range from endothelial cells to macrophages to pancreatic ductal adenocarcinoma (PDAC). B, summary of pro-angiogenic HA signaling starting with synthesis of HA from GlcUA and GlcNAc by HASs at the plasma membrane and ending with the subsequent degradation of HMW HA into LMW polysaccharides.