Table 2.
Baseline Demographic and Clinical Characteristics of Subjects Receiving Transcranial Photobiomodulation in NIR and Sham Mode
| NIR (n = 10) | Sham (n = 11) | p | |
|---|---|---|---|
| Demographic characteristics | |||
| Age, years, mean (SD) | 45.0 (12.8) | 50.7 (13.3) | ns |
| Gender, female, n (%) | 6 (60) | 6 (56) | ns |
| Race, n (%) | ns | ||
| White | 9 (90) | 10 (91) | |
| Black or African American | 0 | 1 (9) | |
| Asian | 1 (10) | 0 | |
| Ethnicity, n (%) | |||
| Non-Hispanic | 10 (100) | 11 (100) | |
| Clinical characteristics, mean (SD) | |||
| HAM-D17 total score | 20.6 (3.2) | 20.2 (4.3) | ns |
| CGI-severity | 4.4 (0.5) | 4.4 (0.5) | ns |
| Months of current MDD episode | 14.5 (15.4) | 19.9 (22.0) | ns |
| Age of MDD onset | 15.5 (6.7) | 31.6 (19.6) | ns |
| Number of MDD episodes | 4.3 (1.7) | 2.6 (1.8) | 0.047 |
| Number of hospitalizations | 1.0 (1.3) | 1.3 (2.4) | ns |
| Current antidepressant treatment, n (%) | |||
| None | 5 (50) | 7 (64) | |
| Psychotherapy alone | 2 (20) | 1 (9) | |
| Antidepressant medication(s)—no psychotherapy | 3 (30) | 1 (9) | |
| Antidepressant medication(s) and psychotherapy | 0 | 2 (18) | |
ns, nonsignificant (p > 0.05).
CGI, Clinical Global Impression; HAM-D17, Hamilton Depression Rating Scale; MDD, major depressive disorder; NIR, near infrared radiation; SD, standard deviation.