Fig. 1.

Probable entry of SARS-CoV2 into CNS: SARS-CoV2 is known to conventionally enter the lungs, through the nasal passage and its cargo to lower respiratory tract and different peritoneal organs (1). However, SARS-CoV2 can also enter the CNS through several probable routes. SARS-CoV2 can enter by retrograde axonal transport through nasal epithelia to the olfactory bulb via olfactory neurons and get direct access to the brain parenchyma by trans-neuronal spread (2). SARS-CoV2 can possibly transport from the lungs to the brainstem and spinal cord via the lung-brain axis (3). Moreover, SARS-CoV2 can also follow an enteric route through gut-CNS axis via parasympathetic vagus nerve (4). SARS-CoV2 can also enter the CNS upon viremia and breeching of the blood-brain barrier (BBB) (5)