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. 2021 Jan 27;58(3):298–311. doi: 10.3892/ijo.2021.5178

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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circUBAP2 promotes OS cell proliferation, migration and invasion, and inhibits OS cell apoptosis by regulating HMGA2. (A) Transfection efficiency of pcDNA3.1-HMGA2. (B) Effect of circUBAP2 and HMGA2 on HOS and SaOS-2 cell proliferation as determined by performing Cell Counting Kit-8 assays. (C) Effect of circUBAP2 and HMGA2 on HOS and SaOS-2 cell (C) migration and (D) invasion as determined by performing Transwell assays (scale bar, 500 µm). (E) Effect of circUBAP2 and HMGA2 on HOS and SaOS-2 cell apoptosis as determined via flow cytometry. ^**P<0.01 vs. pcDNA3.1. circ, circular RNA; UBAP2, ubiquitin associated protein 2; OS, osteosarcoma; HMGA2, high mobility group A2; si, small interfering RNA; NC, negative control; OD, optical density; d, days.