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. 2021 Jan 20;22(3):1026. doi: 10.3390/ijms22031026

Table 3.

Interventional clinical trials employing microbial products of hematological malignancies treatment and its complications.

Condition Intervention Administration Primary Aim Phase Participants Status Identifier
aGvHD FMT Orally via capsule Efficacy, safety, and tolerability I 10 NYR NCT04280471
GI aGvHD FMT Colonoscopy or gastroscopy Efficacy and safety II 30 R NCT03812705
GI aGvHD FMT Nasojejunal tube Efficacy and safety I 15 NYR NCT03549676
GI aGvHD FMT Orally via capsule Efficacy and safety I/II 20 R NCT04269850
GI aGvHD FMT Orally via capsule Efficacy and safety II 17 NYR NCT04059757
GI aGvHD FMT Colonoscopy or gastroscopy Efficacy III 15 R NCT03819803
GI aGvHD FMT Orally via capsule Efficacy and safety N/A 10 R NCT04622475
aGvHD FMT Orally via capsule Feasibility and efficacy I 11 NYR NCT04139577
GI aGvHD FMT Colonoscopy or duodenal nutrition tube injection Efficacy I 30 R NCT04285424
Allo-HSCT, AML FMT Orally via capsule Efficacy and incidence of infections II 120 R NCT03678493
AML FMT Rectal enema Evaluation in dysbiosis correction and in MDRB eradication I/II 20 C NCT02928523
aGvHD FMT Not specified Efficacy II 24 C NCT03359980
Allo-HSCT FMT Orally via capsule Feasibility and efficacy I 18 C NCT02733744
Allo-HSCT Potato-based dietary starch Orally Incidence of grade II-IV GVHD II 70 R NCT02763033
Allo-HSCT Fructo-oligosaccharides prebiotic Orally Safety and tolerability I 15 C NCT02805075
Allo-HSCT Galacto-oligosaccharide prebiotic Orally Tolerability and incidence of Grade II-IV aGVHD I/II 128 NYR NCT04373057
Allo-HSCT Human lysozyme goat milk prebiotic Orally Safety and tolerability I 36 NYR NCT04177004
Allo-HSCT Clostridium butyricum CBM 588 Probiotic Strain Orally Safety I 36 R NCT03922035

AML acute myeloid leukemia; Allo-HSCT allogeneic hematopoietic stem cell transplant; FMT fecal microbiota transplant; GI gastrointestinal; GvHD graft versus host disease; HSCT hematopoietic stem cell transplant; MDRB multidrug resistant bacteria; NYR, Not yet recruiting; R recruiting; C completed.