Figure 2.

Representative drug screen results of four out of eleven tested monotherapies. For all monotherapies, the IC50 exceeded the Cmax and Css values. This suggests that monotherapy drug concentrations needed to achieve 50% cell death could not be achieved in vivo. Since the Log₁₀ (Css) of tamoxifen is below 0, the Css is not displayed. Additionally, the concentration tamoxifen needed to achieve 10% cell death (IC10) also exceeded the Css. Each curve represents the average response of three biological replicates and two technical replicates. The Z-factor was ≥0.8 for all drug screens. IC50: concentration needed to obtain 50% cell death; IC10: concentration needed to obtain 10% cell death; Cmax: maximum drug concentration achieved in plasma; Css: steady state drug concentration in plasma.