. 2021 Jan 20;10(3):385. doi: 10.3390/jcm10030385

Table 2.

Effects of exercise interventions on hepatokines.

Hepatokines	Exercise Intervention		Effects	Refs
Hepatokines	Exercise Type	Frequency	Effects	Refs
Andropin	Aerobic	90 min, 3-5 days/weeks	Increased serum andropin, thus reducing arterial stiffness and improving endothelial function.	Fujie et al. [29] Zhang et al. [30]
ANGPTL4	Aerobic	120 min, single bout	Selective induction of ANGPTL4 reduces the local fatty acid uptake, while directing fattiy acid to active skeletal muscle as a fuel.	Catoire et al. [31]
Fetuin A, Fetuin B, FGF21	Aerobic	30–45 min/day, 3 days a week, 8 weeks	Prevention of type 2 diabetes. Greater improvement in hepatokines was observed in resistance exercise.	Keihanian et al. [32]
Fetuin A, Fetuin B, FGF21	Resistance	Leg press, bench press, knee extension, seated cable row, knee flexion, military press, and calf rise, 3 days/week, 8 weeks		Keihanian et al. [32]
FST	Aerobic	12 m/min, 30 min, and increasing up to 30 m/min, 60 min	Both exercises increased FST in rats, which can be of use in addressing muscular disorders.	Rashidlamir et al. [33]
FST	Resistance	3 sets of 5 repetitions, 3 sessions per week for 8 weeks		Rashidlamir et al. [33]

Abbreviations: ANGPTL4, angiopoietin-like protein 4; FGF21, fibroblast growth factor 21; FST, follistatin.