Data were collected over a 7-day period on 9 separate mission time points: Lā180, Lā60, FD10, FD90, R-1, R+0, R+18, R+33, R+66. Time points are n days before launch (Lān), n days into flight (FDn), and n days after return to Earth (R+n). B, single blood collection; S, saliva collection; U, single 24-h urine collection; H, health assessment, Profile of Mood States-Short Form and Pittsburgh Sleep Quality Index.