Salivary C-reactive protein (CRP; A), lactoferrin (B), and HNP 1–3 (C) are not affected by an International Space Station (ISS) spaceflight mission: concentration, secretion, and osmolarity-adjusted concentration in ISS crewmembers and ground-based control subjects during an ISS mission. Values are means ± SE. Time points are n days before launch (L−n), n days into flight (FDn), and n days after return to Earth (R+n). No differences were found between rookie and veteran crewmembers or between viral shedders and nonshedders (data not shown).