Fig. 2.

Effect of chronic hyperinsulinemia on glucose metabolism pathways in the fetal liver. A: expression of genes involved in glycolysis, glucose oxidation, lactate metabolism, and gluconeogenesis measured in liver of control (CON) and hyperinsulinemic (INS) fetuses. B: heatmap showing normalized relative intensity of metabolites related to glycolysis and pentose phosphate pathway. Quantitative changes are color coded from blue (low) to red (high). C: fetal hepatic glycogen content. Means ± SE are shown (n = 8 CON and 7 INS). *P < 0.05 in CON vs. INS.