Table 2.

Co-occurrence of frequently altered immune genes in the TCGA pan-cancer LUAD dataset (n = 507). Queried genes (IFNG, IL10, IL6, CD4, B2M, CD274, MMP7, HAVCR2, PDCD1, IL17A, CXCR2, TNF, MMP12, CXCL6, NFKB1, PPBP, CXCR1, NFKB2, TGFB1, IL18, CTLA4, CCR2, CXCL1, CXCL2, CXCL8, IL13, SPP1, IL1B, IL4, CCL2, CD8A) were never mutually exclusive but frequently co-occurring (COOC; indicating oncogene addiction). p, probability, hypergeometric test; q, probability, false discovery rate. Data are freely available at https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018 [43,44].

A	B	Neither	A Not B	B Not A	Both	Log2 Odds Ratio	p-Value	q-Value	Tendency
MMP7	MMP12	492	6	0	9	>3	<0.001	<0.001	Co-occurrence
CXCL1	CXCL8	501	1	0	5	>3	<0.001	<0.001	Co-occurrence
CXCL2	CXCL8	501	1	0	5	>3	<0.001	<0.001	Co-occurrence
PPBP	CXCL8	500	2	0	5	>3	<0.001	<0.001	Co-occurrence
CXCL1	CXCL2	500	1	1	5	>3	<0.001	<0.001	Co-occurrence
CXCL6	CXCL8	499	3	0	5	>3	<0.001	<0.001	Co-occurrence
PPBP	CXCL1	499	2	1	5	>3	<0.001	<0.001	Co-occurrence
PPBP	CXCL2	499	2	1	5	>3	<0.001	<0.001	Co-occurrence
CXCL6	CXCL1	498	3	1	5	>3	<0.001	<0.001	Co-occurrence
CXCL6	CXCL2	498	3	1	5	>3	<0.001	<0.001	Co-occurrence
CXCL6	PPBP	497	3	2	5	>3	<0.001	<0.001	Co-occurrence
IL13	IL4	501	2	1	3	>3	<0.001	<0.001	Co-occurrence
TGFB1	IL18	496	4	4	3	>3	<0.001	0.002	Co-occurrence
MMP12	IL18	494	6	4	3	>3	<0.001	0.004	Co-occurrence
MMP7	IL18	488	12	4	3	>3	<0.001	0.021	Co-occurrence