Figure 3.

Effects of ERr 731 and E₂ on T_skin persisted for one week of treatment. (A) Recordings of OVX controls (red) show circadian rhythm and increased T_skin as compared to intact (Sham, black) animals, while E₂ treatment (blue) is associated with decreased T_skin on day 7; (B) Average T_skin is significantly increased in OVX rats and reduced following E₂ treatment in the dark phase of day 7; (C) Recordings of decreased T_skin following ERr 731 treatment (green) on day 7; (D) Average T_skin is significantly reduced in ERr 731-treated rats in the dark phase of day 7. Data are the mean ± SEM (n = 6), * p < 0.05 vs. OVX control.