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. 2021 Jan 21;22(3):1031. doi: 10.3390/ijms22031031

Table 1.

Aldose reductase inhibitors described in this article.

Name Epalrestat
(Kinedak®)		 Fidarestat
(SNK-860)		 Ranirestat
(AS-3201)
Molecular Formula C15H13NO3S2 C12H10FN3O4 C17H11BrFN3O4
Molecular Weight 319.4 279.2 420.2
International Union of Pure and Applied Chemistry
(IUPAC) Name		 2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid (2S,4S)-6-fluoro-2’,5’-dioxospiro[2 ,3-dihydrochromene-4,4’-imidazolidine]-2-carboxamide (3R)-2’-[(4-bromo-2-fluorophenyl)methyl]
spiro[pyrrolidine-3,4’-pyrrolo[1,2-a]pyrazine]-1’,2,3’,5-tetrone
Chemical Structure graphic file with name ijms-22-01031-i001.jpg graphic file with name ijms-22-01031-i002.jpg graphic file with name ijms-22-01031-i003.jpg
Current Status It is commercially available in Japan Its development was terminated Its development was terminated