Figure 13:

(A) Fluorescence imaging of the 4T1 tumor-bearing mice with given dose of 30 nmol HPPH equivalent. At 24 h post injection, the tumor fluorescence intensity of GO(HPPH)-PEG-HK (targeted) was significantly higher than other probes. (B) Quantification of %ID/g uptake of HPPH (photosensitizer), GO(HPPH)-PEG (untargeted) and GO(HPPH)-PEG-HK (targeted) in tumor and other organs. The uptake was significantly higher with targeted nanoparticles in tumor. Adapted with permission from (Yu, X.; Gao, D.; Gao, L.; Lai, J.; Zhang, C.; Zhao, Y.; Zhong, L.; Jia, B.; Wang, F.; Chen, X.; Liu, Z., Inhibiting Metastasis and Preventing Tumor Relapse by Triggering Host Immunity with Tumor-Targeted Photodynamic Therapy Using Photosensitizer-Loaded Functional Nanographenes. ACS Nano 2017, 11 (10), 10147–10158). Copyright (2017) American Chemical Society.[95]