Table 1.

Selected findings in Chilean daughters of women with PCOS

	Infancy (age 2–3 months)	Mid- to late childhood; prepubertal	Early puberty (Tanner 2–3)	Late puberty (Tanner 4–5 and/or postmen archeal)	Peripubertal (age 8–16 years, Tanner 1–5)
Putative feature of PCOS	References 17, 22	References 17, 18, 20, 21, 23, 24	References 20, 23, 24	References 20, 23–25	References 18, 19, 21
Higher total testosterone	−	−	−	+	+
Lower sex hormone-binding globulin	−	−	−	+	+/−
Higher free testosterone estimate		−	−	+	+
Higher androstenedione	−	−	−	−	−
Higher 17-hydroxyprogesterone	−	−	−	(−)	−
Higher dehydroepiandrosterone sulfate		−			+
More hirsutism		−	−	+
Exaggerated 17-hydroxyprogesterone responsiveness (GnRH agonist)	−	−	−	+/−
Exaggerated androstenedione responsiveness (GnRH agonist)	−			+
Exaggerated testosterone responsiveness (GnRH agonist)	−	−	−	+/−
Exaggerated estradiol responsiveness (GnRH agonist)	+
Exaggerated 17-hydroxyprogesterone responsiveness (exogenous ACTH)		+			+
Exaggerated dehydroepiandrosterone responsiveness (exogenous ACTH)		+			+
Higher LH	−	−	−	(−)	−
Lower FSH	−	(−)	−	−	−
Higher LH-to-FSH ratio		−	−	(−)
Higher GnRH agonist-stimulated LH	+	−	−	+
Higher anti-Müllerian hormone	+	+	+	+	+
Greater ovarian volume		+	+	+	+
Greater global adiposity (e.g., BMI z-score)	−	−	−	−	−
Higher waist circumference	−	−	−	−	−
Higher waist-to-hip ratio	−	−	−	−	−
Higher fasting insulin		−	−	(−)	−
Higher fasting glucose		−	−	−	−
Higher insulin after oral glucose load		+	+	+	+
Insulin resistance by oral glucose tolerance test		−	−	+/−
Higher triglycerides		−	−	+/−	+
Lower adiponectin		+	−	−	−
Higher leptin		−	−	−	−

Key: “+” = available data suggests presence; “+/−” = data mixed; “(−)” = most but not all data suggests against presence; “−” = available data suggests against presence; blank = data not reported in these studies.