Fig 2. Adverse events recorded in 56 randomised controlled trials testing bisphosphonates over no bisphosphonates.

The left panel is the estimated difference in risk (with 95% confidence intervals) between the bisphosphonate and no-bisphosphonate arms from a fixed effects meta-analysis of studies with this comparison, and the right panel is the estimated odds ratio. Highlighted black are those adverse events where the treatment effect is both statistically and practically significant, where practical significance is defined by an estimated odds ratio >1.5 or risk difference >0.02.