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. 2021 Feb 5;16(2):e0246328. doi: 10.1371/journal.pone.0246328

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© 2021 Xia et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — The difference in THI before and after the treatment of STEC (upper panels) and EC alone (the lower panels). A and C: The pre- and post-THI scores. B and D: the pre-post difference of THI score. STEC resulted in a significant THI reduction in both years (A), but there was no significant difference in the amount of reduction between years and between subjects with and without anxiety (B). EC alone reduced THI in 2019, but opposite in 2020 (C and D). The THI got deteriorated in 2020 and worse than 2019 in both subgroups with and without anxiety (D). Therefore, within subjects with or without anxiety, the treatment resulted in a better THI in year 2019. STEC: sound therapy + educational counseling, EC: educational counseling.