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. 2021 Feb 5;16(2):e0246027. doi: 10.1371/journal.pone.0246027

Table 2. Accuracy and cut points of individual biomarkers and combinations of biomarkers for diagnosis of SBI on admission to PICU.

Individual biomarker or biomarker combinations AUC (95% CI) Cut-point# Sensitivity 95% CIs Specificity 95% CIs PPV 95% CIs NPV 95% CIs LR+ 95% CIs LR- 95% CIs
PCT (ng/ml) * 83.73 (78.11, 89.35) 1.25 0.78 (0.69, 0.88) 0.80 (0.76, 0.84) 0.37 (0.26, 0.48) 0.96 (0.94, 0.98) 3.92 (3.17, 4.85) 0.27 (0.17, 0.42)
Urine NGAL (ng/ml) 56.72 (48.18, 65.25) 95.10 0.47 (0.34, 0.60) 0.67 (0.62, 0.71) 0.17 (0.07, 0.27) 0.90 (0.87, 0.93) 1.41 (1.03, 1.93) 0.79 (0.61, 1.03)
Plasma NGAL (ng/ml) 68.07 (60.09, 76.06) 194.00 0.61 (0.49, 0.73) 0.75 (0.69, 0.81) 0.38 (0.26, 0.50) 0.88 (0.84, 0.93) 2.44 (1.81, 3.30) 0.52 (0.37, 0.72)
Resistin (ng/ml) 80.17 (73.14, 87.20) 96.28 0.64 (0.51, 0.76) 0.85 (0.80, 0.90) 0.51 (0.38, 0.65) 0.90 (0.86, 0.94) 4.20 (2.90, 6.10) 0.43 (0.30, 0.61)
APTT slope 65.90 (58.89, 72.92) -0.03 0.46 (0.35, 0.57) 0.84 (0.81, 0.87) 0.33 (0.23, 0.43) 0.90 (0.87, 0.93) 2.86 (2.09, 3.92) 0.65 (0.53, 0.79)
APTT TR18 (%) 67.23 (60.29, 74.17) 99.40 0.51 (0.40, 0.62) 0.84 (0.81, 0.87) 0.35 (0.25, 0.45) 0.91 (0.88, 0.93) 3.13 (2.32, 4.22) 0.59 (0.47, 0.74)
CRP mg/l 89.76 (85.83, 93.69) 2.09 0.93 (0.87, 0.99) 0.76 (0.72, 0.79) 0.37 (0.25, 0.48) 0.99 (0.98, 1.00) 3.81 (3.21, 4.52) 0.09 (0.04, 0.22)
Model (1) ‡ PCT, Resistin, pNGAL, CRP 91.64 (87.58, 95.70) 0.12 0.92 (0.84, 1.00) 0.83 (0.77, 0.89) 0.57 (0.42, 0.73) 0.98 (0.95, 1.00) 5.42 (3.77, 7.79) 0.10 (0.03, 0.28)
Model (2) ‡ PCT, Resistin, APTT TR18, CRP 92.52 (88.22, 96.81) 0.08 0.97 (0.92, 1.00) 0.75 (0.67, 0.82) 0.52 (0.35, 0.68) 0.99 (0.97, 1.00) 3.83 (2.82, 5.19) 0.04 (0.01, 0.27)
Model (3) ‡ PCT, Resistin, CRP 92.36 (88.54, 96.17) 0.10 0.95 (0.88, 1.00) 0.79 (0.73, 0.86) 0.54 (0.38, 0.69) 0.98 (0.96, 1.00) 4.54 (3.30, 6.23) 0.06 (0.02, 0.25)
Model (4) ‡ PCT, CRP 92.66 (88.47, 96.85) 0.06 0.92 (0.85, 0.99) 0.86 (0.83 0.90) 0.50 (0.37, 0.62) 0.99 (0.97, 1.00) 6.67 (5.18, 8.58) 0.10 (0.04, 0.22)

*Pre-test probability is 12.89%.

#Cut-points were determined using the Youden Index, and probability cut-points were given for biomarker combinations from models (1)-(4), see below.

‡Prediction via logistic regression models:.

Model (1): p=−2.68+6.31×10−3PCT+1.45×10−3Resistin+0.46×10−3pNGAL+14.79×10−3CRP.

Model (2): p=0.85+5.64×10−3PCT+1.73×10−3Resistin−36.34×10−3APTT+20.10×10−3CRP.

Model (3): p=−2.60+7.29×10−3PCT+1.73×10−3Resistin+15.16×10−3CRP.

Model (4): p=−2.96+27.02×10−3PCT+18.49×10−3CRP.