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Comparison of the number of records with low (pKa < 6) and high (pKa > 8) basicity for the considered targets. In brackets, the fraction of basic ligands among all active compounds is provided.
| 5-HT1B | 5-HT2A | 5-HT2B | 5-HT2C | |
|---|---|---|---|---|
| Low basicity | 8 (1.04%) | 228 (7.66%) | 229 (22.50%) | 329 (17.06%) |
| High basicity | 584 (75.75%) | 2005 (67.35%) | 613 (60.22%) | 1258 (65.25%) |
| Total number of ligands | 771 | 2977 | 1018 | 1928 |
