Figure 1.

Schematic shows known full-length GLIoma-associated oncogene homolog (GLI) family functional domains at the transcriptional level. Similarities shared among all three types include Suppressor of fused (SUFU) binding sites, zinc finger DNA-binding domain, and activation domains. GLI1 has an additional SUFU binding site at the C-terminus, while GLI2/3 has repressor domains; additionally, GLI2 has an extra activation domain that supports its main feature of activating GLI-mediated transcription.