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. 2021 Jan 21;22(3):1042. doi: 10.3390/ijms22031042

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic shows the role of GLI1 and GLI2 in cancer cell proliferation, migration, invasion, cell cycle regulation, angiogenesis, cell signaling, and survival kinases activation. Tumor suppressors downregulated by GLI are shown in red.