Table 1.

Therapeutic strategies against viral diseases.

Hh Inhibitors	Disease	Mechanism of Action
Vismodegib (GDC-0449)	HBV and HCV	Decreases liver fibrosis in human Decreases tumor formation in a mouse model of fibrosis-associated HCC
		Reduces the growth of HBV X-expressing tumor xenografts in nude mice and HCC formation in transgenic mice expressing the HBV X protein
GLI inhibitors: GANT-61	EBV and EBV linked Nasopharyngeal cancer	Reduces the pro-fibrotic effects Inhibits autophagy in HCV-exposed fibroblasts
		Reduces tumor-sphere formation in several EBV-infected cell lines
	HPV	Decreases the proliferation of Human Papilloma Virus-derived cervical cancer cells
GLI agonist	HIV	Targeted against local uninfected environment
Smoothened agonist		Targeted against HIV infected Cells. Limits viral niche.