Table 3.

Clinical applications of mesenchymal stem cells in burns (CMSCs—cadaveric bone marrow mesenchymal stem cells, NA—not available, AMSG—autologous meshed skin grafting, FMSC—fibroblast-like bone marrow mesenchymal stem cells, SG—skin grafts, BMSCs—bone marrow mesenchymal stem cells, UC-MSCs—umbilical cord blood-derived mesenchymal stem cells, TBSA—total body surface area).

Therapy	Compared To	Route and Number of Administrations	Burn Characteristics	Follow Up	# of Patients	Age Range [Years]	Result	Author	Year
allogeneic FMSC	NA	transplantation on the surface of the wound; followed by SG	extensive skin burn	NA	1	45	promoted and accelerated healing	Rasulov et al. [68]	2005
sweat gland-like cell derived from BMSCs	NA	cells transplanted to the wound, covered with a decellularized allogeneic dermal matrix with numerous laser-punched holes, granulated autologous skin grafting, and allogeneic skin	burn scars devoid of perspiration function	NA	5	7–21	recovery of perspiration function	Sheng et al. [69]	2008
autologous cultured BMSCs + skin graft	skin graft alone	cell injection to the wound	extensive skin burn,	2 years	1	19	smaller risk of contraction of the skin graft	Xu et al. [70]	2012
CMSCs	NA	2 applications of CMSCs followed by AMSG	deep skin burns	3 years	1	26	almost no scar or deformity in the places treated with CMSCs	Mansilla et al. [71]	2015
BMSCs and UC-MSCs	early excision and graft	cell injection to the wound	full thickness burn, 10–25% TBSA	6 months	60	BMSC: 20–27; UC-MSC: 18–29; CT: 18–35	reduced hospitalization time in both BMSC and UC-MSC group	Abo-Elkheir et al. [72]	2017