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. Author manuscript; available in PMC: 2021 Mar 18.
Published in final edited form as: J Am Chem Soc. 2020 Mar 4;142(11):5017–5023. doi: 10.1021/jacs.0c01330

Table 1.

Ligand Evaluation of XEC Reaction of Unactivated 1,3-Dimesylates

graphic file with name nihms-1661740-t0011.jpg
Entry Deviation from reaction conditions Yielda (%)
1 none 75
2 BPhen 78
3 dppm 71
4 PCy3 56
5 DPEPhos 44
6 SiMes*HBF4 33
7 Xantphos 16
8 no ligand 13
9 ((R)-BINAP)NiCI2 70
10 PhMgBr 5
11 PhMgBr + Mgl2 17
12 no Ni, no ligand 5
13 no MeMgl 0
a

Yield determined by 1H NMR based on comparison to PhTMS as internal standard.