FIGURE 1.

(a) Schematic diagram for the study design of the recipient animals. The SS^CD247−/− animals maintained on a low-salt (LS) diet were mated. On postnatal day 5, some recipient pups received a splenocyte transfer from either LS- or high-salt (HS)-fed animals, whereas other pups did not receive a transfer. All the pups were weaned to, and maintained on, an LS diet. After telemetry implantation surgery at 7 weeks of age and subsequent recovery and baseline recordings, all animals were switched to an HS diet for 21 days. (b,c) Sodium excretion (b) and albuminuria (c) of the salt-sensitive (SS) donors (n = 11/11) at baseline and after 21 days of the LS (SS LS) or HS (SS HS) diet. ***P < 0.001 versus SS LS. Two-way repeated-measures ANOVA with the Holm–Sidak post hoc test was used, and the P-values for the main effects are reported in each graph