TABLE 1.
Obese T2D n = 28 | Non-obese T2D n = 12 | Non-diabetic controls n = 12c | |
---|---|---|---|
Sex, male/female | 14/14* | 11/1 | 10/2 |
Ancestry, Caucasian, # | 11 | 5 | 9 |
African American, # | 17 | 4 | 3 |
Asian, # | 0 | 3 | 0 |
Age, years | 54.7 ± 1.8 | 58.8 ± 2.5 | 32.2 ± 2.3† |
Diabetes duration, years | 3.9 ± 0.8 | 4.8 ± 1.5 | NA |
BMI, kg/m2 | 35.5 ± 0.8* | 25.0 ± 0.7 | 25.1 ± 0.8 |
Fasting glucose, mg/dLa | 130 ± 3 | 126 ± 3 | 91 ± 3† |
Fasting insulin, μU/mLb | 21.5 ± 2.7* | 13.1 ± 1.9 | 7.5 ± 0.9† |
Fasting proinsulin, pmol/L | 29.2 ± 2.9 £ | 20.6 ± 2.0 | 8.3 ± 1.6† |
One-hour glucose, mg/dLa | 240 ± 8 | 255 ± 14 | 125 ± 13‡ |
Two-hour glucose, mg/dLa | 237 ± 10 | 228 ± 13 | 93 ± 7‡ |
HbA1c, % | 6.5 ± 0.1 | 6.5 ± 0.1 | ND |
Note: Data are means ± SE. T2D, type 2 diabetes; NA, not applicable; ND, not done. One-hour and two-glucose levels were derived from a standard 75 g oral glucose tolerance test (OGTT).
To convert units to mmol/L, multiply by 0.05551.
To convert units to pmol/L, multiply by 7.175.
n = 8 for the OGTT.
P ≤ .05 when comparing obese T2D to non-obese T2D subjects;
P ≤ .05 when comparing non-obese T2D to non-diabetic controls;
P < .1 when comparing obese T2D to non-obese T2D subjects;
P < .001 when comparing non-obese T2D to non-diabetic controls.