Figure 8.
Numerical simulations of MNP balloon implant heating. (A) Temperature-dependent blood perfusion scaling function F(T); (B) Simulated temperature as a function of time at the implant surface and radially 5-mm (tumor edge) and 10-mm from the surface of a 3-cm diameter balloon; (C) Simulated temperatures around 2, 3, 4, and 5 cm diameter TBT balloons implanted in tumor resection cavities in well-perfused white matter. (D) Simulated cumulative temperature-volume histograms for 2, 3, 4, and 5 cm diameter balloons heating a 5-mm annular rim target of perfused white matter. Note that for all size balloons, 100% of the 5-mm annular tumor bed target is heated above 40°C and about 50% of the target volume is heated above 41.8°C for balloon surface temperatures of 46.2 – 48.5°C.