Fig 4.

Performance characteristics of the best model for predicting concomitant Alzheimer’s disease (AD) pathology among non-Penn, NACC cases with neuropathological evidence of Lewy bodies and presumed clinical diagnosis of LBD. a Receiver operating characteristic (ROC) curve and area under the curve (AUC) of the final model (developed in the Penn-based Training set, with age at disease onset, number of APOE4 alleles, BIN1 genotype, and SORL1 genotype as predictors) are shown. b The Alzheimer’s Disease Neuropathological Change Risk Score (ADNC-RS) calculated from the final model is shown for LBD cases from the NACC. Individuals positive for ADNC showed higher average ADNC-RS. c Despite the NACC database’s enrichment for ADNC-positive individuals compared to the Penn-based cases (Training and Test sets combined), the ADNC-RS correlated with prevalence of ADNC in both groups.