Table 3.

Genetic loci nominated from Alzheimer’s disease GWAS literature.

Variant	Chr.	Positiona	Nearest Geneb	Maj/ Min	MAFc	Reported OR (95%CI) for ADd
rs3818361e	1	207611623	CR1	G/A	0.278	1.20 (1.13–1.27)
rs6733839	2	127135234	BIN1	C/T	0.399	1.20 (1.17–1.23)
rs7570320f	2	233167045	INPP5D	C/A	0.369	0.92 (0.87–0.97)
rs9271100g	6	32608701	HLA-DRB5/DRB1	C/T	0.273	1.11 (1.06–1.17)
rs75932628	6	41161514	TREM2	C/T	0.010	2.08 (1.73–2.49)
rs10948363h	6	47520026	CD2AP	A/G	0.278	1.09 (1.06–1.12)
rs1476679i	7	100406823	NYAP1j	C/T	0.323	0.92 (0.90–0.95)
rs11762262k	7	143410783	EPHA1	C/T	0.207	0.91 (0.86–0.96)
rs17057043l	8	27362793	PTK2B	G/A	0.343	1.11 (1.06–1.16)
rs11136000m	8	27607002	CLU	C/T	0.369	0.88 (0.85–0.90)
rs11257240n	10	11677075	ECHDC3	T/G	0.350	1.07 (1.02–1.12)
rs920573o	11	60157486	MS4A6A	G/A	0.475	0.90 (0.86–0.95)
rs3851179	11	86157598	PICALM	C/T	0.429	0.88 (0.86–0.90)
rs11218343	11	121564878	SORL1	T/C	0.040	0.80 (0.75–0.85)
rs17125944p	14	52933911	FERMT2	T/C	0.081	1.14 (1.09–1.18)
rs10498633q	14	92460608	SLC24A4	G/T	0.182	0.92 (0.89–0.94)
rs11854073r	15	58680796	ADAM10	G/A	0.308	0.93 (0.91–0.95)
rs3752246	19	1056493	ABCA7	C/G	0.187	1.15 (1.11–1.18)
rs7274581s	20	56443204	CASS4	T/C	0.091	0.88 (0.85–0.92)

^aGRCh38.

^bBased on position of top SNP in reference to RefSeq assembly.

^c1000 Genomes, CEU population.

^dReported by Kunkle et al (2019).

^eproxy rs4844610 (D’=1.0),

^fproxy rs10933431 (D’=0.84),

^gproxy rs9271058 (D’=1.0),

^hproxy rs9473117 (D’=1.0),

ⁱproxy rs12539172 (D’=0.98),

^jPreviously the ZCWPW1 locus,

^kproxy rs10808026 (D’=1.0),

^lproxy for rs73223431 (D’=1.0),

^mproxy rs9331896 (D’=1.0),

ⁿproxy rs7920721 (D’=0.95),

^oproxy rs7933202 (D’=0.94),

^pproxy rs17125924,

^qproxy rs12881735 (D’=1.0),

^rproxy rs593742 (D’=0.88),

^sproxy rs6024870 (D’=0.94).