Table 4.
Associations between individual genetic loci and presence of concomitant AD pathology. Logistic regression coefficients (β), standard error (SE), and nominal p-values are shown. No covariates are included. TREM2 is omitted from analysis due to lack of genetic variation at this SNP in the Training set.
| Locus | β | SE | Nominal p-value |
|---|---|---|---|
| APOE E4 | 1.049 | 0.269 | 0.000 |
| APOE E2 | −0.667 | 0.538 | 0.215 |
| CR1 | 0.308 | 0.242 | 0.203 |
| BIN1 | 0.191 | 0.206 | 0.354 |
| INPP5D | −0.180 | 0.187 | 0.335 |
| HLA-DRB5/DRB1 | 0.068 | 0.229 | 0.768 |
| CD2AP | 0.007 | 0.230 | 0.976 |
| NYAP1a | −0.149 | 0.281 | 0.596 |
| EPHA1 | −0.255 | 0.264 | 0.333 |
| PTK2B | −0.109 | 0.215 | 0.610 |
| CLU | −0.057 | 0.225 | 0.799 |
| ECHDC3 | −0.147 | 0.217 | 0.499 |
| MS4A6A | 0.313 | 0.211 | 0.138 |
| PICALM | 0.009 | 0.212 | 0.967 |
| SORL1 | 1.204 | 0.650 | 0.064 |
| FERMT2 | 0.195 | 0.394 | 0.620 |
| SLC24A4 | −0.022 | 0.302 | 0.942 |
| ADAM10 | 0.321 | 0.253 | 0.204 |
| ABCA7 | 0.040 | 0.252 | 0.875 |
| CASS4 | −0.028 | 0.281 | 0.921 |
a
Previously the ZCWPW1 locus.
*
p<0.05.