Table 5.
Demographic and Clinical Characteristics of NACC Validation Set. Data represent mean (SEM) unless otherwise noted.
| Characteristic | Whole Dataset | None/Low ADNC | Intermediate/High ADNC | p-value b |
|---|---|---|---|---|
| N | 70 | 8 | 62 | |
| Age at Onset, y | 70.49 (1.03) | 69.50 (3.55) | 70.61 (1.08) | 0.634 |
| Age at Death, y | 80.41 (0.98) | 80.25 (4.03) | 80.44 (0.99) | 0.939 |
| Disease Duration, y | 9.93 (0.54) | 10.75 (1.89) | 9.82 (0.56) | 0.474 |
| Sex, (F/M), N (%) | 23 (32.9)/ 47 (67.1) | 1 (12.5)/ 7 (87.5) | 22 (37.5)/ 40 (62.5) | 0.2572 |
| Race, N (%) White | 70 (100.0) | 8 (100.0) | 62 (100.0) | >0.999 |
| Non-White | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Last MMSEa | 19.34 (1.377) | 27.2 (0.58) | 18.03 (1.47) | 0.013 |
| Dementia Diagnosis During | 12 (17.1)/ | 5 (62.5)/ | 7 (11.3)/ | 0.003 |
| Life, (No/Yes) N (%) | 58 (82.9) | 3 (37.5) | 55 (88.7) | |
| Lewy Body Distribution, N (%) | ||||
| Diffuse or Neocortical | 44 (62.9) | 5 (62.5) | 39 (62.9) | |
| Transitional or Limbic | 10 (14.3) | 2 (25.0) | 8 (12.9) | 0.558 |
| Brainstem Predominant | 4 (5.7) | 1 (12.5) | 3 (4.8) | |
| Amygdala | 11 (15.7) | 0 (0.0) | 11 (17.7) | |
| Olfactory bulb | 1 (1.4) | 0 (0.0) | 1 (1.6) | |
a
Available data (N = 35).
b
Comparison between None/Low ADNC and Intermediate/High ADNC groups.
*
p<0.05.