Fig. 4. Features of four genomic regions newly associated with face features in the CANDELA sample and replicating in Europeans.

Regional association P values (index SNP is labeled) are shown at the top. Regulatory annotations from human embryonic tissue (27) (combined chromatin states at various Carnegie stages and craniofacial-specific enhancers and superenhancers; the color key for combined craniofacial annotations is in table S6) are provided below each association plot. A heatmap of pairwise LD (r²) in the region is shown at the bottom of each panel. Similar plots for the other previously unidentified regions, detected in the CANDELA sample but not replicating in the European meta-analysis, are shown in Supplementary Notes.