Table 1.

Means and Standard Deviations for Outcome Variables by Product Type.

		Own-Brand Cigarette								JUUL								IQOS
		Pre-Directed		Post-Directed		Pre-Ad Lib		Post-Ad Lib		Pre-Directed		Post-Directed		Pre-Ad Lib		Post-Ad Lib		Pre-Directed		Post-Directed		Pre-Ad Lib		Post-Ad Lib
Outcome Variables		Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Plasma Nicotine^A		2.1	0.2	20.4	11.4	8.8	3.6	21.0	10.2	2.2	0.7	9.8	4.9	4.3	1.8	11.5	9.3	2.1	0.2	12.7	6.2	5.4	1.7	11.3	8.0
CO^A		5.2	2.4	8.7	2.5	8.8	2.8	16.6	7.0	5.5	2.4	5.1	2.3	5.3	2.4	4.7	1.9	5.3	2.0	4.9	1.8	4.6	1.8	4.3	1.4
QSU
	Factor 1^B,C	24.8	8.2	13.2	10.7	21.2	8.9	11.5	10.2	24.7	7.5	20.1	9.3	21.7	9.3	17.8	10.6	25.1	8.2	16.0	9.3	20.4	8.5	14.4	9.7
	Factor 2^C	11.7	8.3	6.9	7.4	9.7	7.4	5.5	7.6	10.3	8.3	8.1	7.8	9.5	7.5	6.5	7.2	12.5	8.4	6.6	7.8	9.1	8.6	6.6	8.9
HH
	Anxious	46.3	32.5	24.8	30.6	22.1	22.8	19.4	27.5	42.8	31.9	24.4	31.8	20.8	30.1	20.4	27.0	44.5	34.9	28.4	33.9	17.2	27.2	28.4	32.6
	Craving^A	75.2	30.7	34.9	35.0	55.2	30.5	25.5	29.2	70.5	30.9	49.3	36.0	54.0	38.0	53.9	34.9	73.5	33.5	42.9	31.8	53.8	29.9	36.2	32.1
	Depression^C	21.4	28.3	9.8	16.8	11.5	21.5	8.8	13.6	15.1	20.9	8.8	16.6	8.1	17.0	8.2	16.3	20.5	26.1	15.1	22.6	10.6	20.1	11.5	21.7
	Diff Concentrate^C	28.2	26.4	18.5	20.4	18.1	20.8	10.4	18.1	37.6	30.1	17.3	19.9	15.5	22.5	17.8	25.8	30.0	31.9	24.4	29.9	16.8	20.6	18.9	27.0
	Drowsy	35.2	25.0	28.7	26.1	24.9	24.3	23.4	26.9	33.8	28.2	21.4	24.6	25.9	31.1	25.3	27.0	31.9	33.9	29.4	26.5	23.4	24.6	27.4	29.8
	Hunger	39.9	22.7	31.9	24.4	34.8	25.9	39.8	30.7	43.2	29.8	35.6	33.3	39.5	35.9	58.4	29.0	43.0	35.5	30.2	25.5	37.7	29.0	53.2	31.9
	Impatient^C	42.1	28.3	23.9	27.3	26.9	29.3	25.5	28.2	41.0	30.6	25.9	31.0	31.4	28.9	31.8	30.5	51.4	31.0	25.1	30.9	29.7	30.3	27.2	27.0
	Irritable^C	37.4	31.0	14.9	17.2	14.1	16.0	14.6	22.0	34.5	31.1	18.4	22.1	15.4	22.3	15.1	26.4	38.7	33.3	19.8	26.3	16.8	21.0	16.8	24.1
	Restless^A	40.8	29.4	19.7	24.8	27.7	27.2	21.5	28.1	30.2	25.5	26.9	25.9	17.9	25.7	24.7	27.6	38.9	31.8	19.7	24.6	33.4	31.4	27.1	28.4
	Sweets	24.2	30.7	16.8	21.4	18.8	25.8	17.9	21.3	27.4	33.3	20.3	27.2	20.7	28.1	17.4	24.0	24.8	28.3	16.4	25.7	23.8	27.9	20.5	27.0
	Urge^A	76.5	25.2	39.2	34.8	54.4	27.6	24.9	25.7	67.2	29.9	48.8	31.9	46.9	33.3	50.0	31.1	74.7	31.5	46.2	29.5	56.9	27.8	38.0	31.8
DEV
	Awake			40.9	31.7			45.1	31.3			33.8	29.9			28.1	29.6			36.5	30.6			34.5	27.4
	Calm			60.9	36.0			60.7	35.3			47.9	31.9			46.6	29.7			54.4	31.5			43.2	34.5
	Concentrate			43.8	30.8			42.0	34.3			24.5	26.3			27.5	26.3			38.5	33.7			27.8	27.1
	Dizzy			40.7	33.4			30.1	36.2			33.7	33.5			19.4	27.2			36.4	34.8			26.9	25.8
	Pleasant^B			81.4	29.8			81.9	24.9			50.4	31.6			50.6	31.2			58.8	36.0			58.9	34.4
	Reduced Hunger			41.9	29.9			33.0	27.7			35.2	27.4			37.1	31.0			29.2	28.8			34.3	26.1
	Right Now			62.8	37.7			44.1	37.7			45.4	32.7			35.5	29.1			47.2	39.1			37.5	33.5
	Satisfy^B			84.3	24.4			83.7	24.5			47.0	33.2			46.5	31.5			58.8	30.9			58.8	33.3
	Sick			4.1	7.5			2.6	5.2			8.1	14.2			7.8	14.4			9.5	19.0			10.5	16.8
	Taste good^B			77.7	29.5			74.0	32.1			50.5	32.6			51.2	30.7			54.6	36.4			49.8	35.7

Means that are significantly different from baseline are presented in bold. Items that are significantly different from own-brand cigarettes at that time point are underlined. Note: CO, expired air carbon monoxide; QSU, Tiffany-Drobes Questionnaire of Smoking Urges-Brief; HH, Hughes-Hatsukami Withdrawal VAS Scale; DEV, Direct Effects of Vaping Questionnaire;

significant interaction,

significant main effect of condition, and

significant main effect of time.