Table 2.
Association of selected SNPs with offspring CHDs in mothers
| Genotype | Control N(%) | Case N(%) | OR (95% CI)a | P valuea |
|---|---|---|---|---|
| rs1801133 | ||||
| CC | 94(30.72) | 108(31.95) | 1 | |
| CT | 159(51.96) | 161(47.63) | 0.74(0.46–1.19) | 0.211 |
| TT | 53(17.32) | 69(20.41) | 5.22(2.29–11.91) | < 0.001 |
| Dominant | 1.06(0.67–1.66) | 0.812 | ||
| Recessive | 6.24(2.87–13.56) | < 0.001 | ||
| Additive | 1.59(1.13–2.22) | 0.007 | ||
| rs1801131 | ||||
| AA | 207(67.65) | 228(67.46) | 1 | |
| AC | 92(30.07) | 91(26.92) | 1.00(0.62–1.62) | 0.996 |
| CC | 7(2.29) | 19(5.62) | 2.18(0.74–6.40) | 0.157 |
| Dominant | 1.12(0.71–1.78) | 0.624 | ||
| Recessive | 2.17(0.77–6.32) | 0.155 | ||
| Additive | 1.19(0.82–1.74) | 0.36 | ||
aAdjusted by gender of children, child-bearing age group, education, occupation, history of abortion, early pregnancy health, smoking, pesticide exposure an drug exposure