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Clamp procedures during hypoglycaemic (a) and hyperglycaemic (b) clamps. Black squares indicate times at which measurements were taken. Target glucose levels (mmol/l) are indicated by the grey arrows at the top. ‘Biochemistry’ includes concentrations of glucose, glucagon, cortisol, ACTH, growth hormone, NEFA and glycerol; HR, heart rate; Iso, isoglycaemic phase of hyperglycaemic clamp; Rec, recovery
