Table 4.

Evidence and recommendations grading

Evidence
Very low quality (VLQ)	Expert opinion supported by one or few small uncontrolled studies
Low quality (LQ)	Supported by large series of small uncontrolled studies
Moderate quality (MQ)	Supported by one or few large uncontrolled studies or meta-analyses
High quality (HQ)	Supported by controlled studies or large series of large uncontrolled studies with sufficiently long follow-up
Recommendations
Discretionary recommendation (DR)	Based on VLQ or LQ evidence
Strong recommendation (SR)	Based on MQ or HQ evidence

Adapted from Giustina et al. [2]